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. 2017 May 23;7:2292. doi: 10.1038/s41598-017-02348-1

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Regulatory effects of the haplotypes constructed from rs4836316, rs2194079 and rs4836317 on the transcriptional activity. The transcriptional activity was decreased when the risk haplotype T-A-G in 293 and C6 cell lines. Bars are presented as fold-induction compared with promoter less vector. Error bars represent standard error of mean (SEM) (n = 5). *P < 0.05.