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. 2017 May 23;7:2309. doi: 10.1038/s41598-017-02654-8

Table 3.

Sensitivity of LEPkit in diagnosis of new cases of acute leptospirosisa using a single serum sample collected at admission-phase as compared to culture and single MAT. (Total number of samples = 74).

Test Day after the disease onset No. positive samples/No. of samples tested % Sensitivity 95% CI
Positive Culture Day 1–3 14/37 37.8% 22.9–55.2%
Day 4–6 4/18 22.2% 7.4–48.1%
Day 7 2/3 66.7% 12.5–98.2%
Unknownb 1/16 6.3% 3.3–32.3%
Total (Culture) 21/74 28.4% 18.8–40.2%
MAT titer ≥1:400 Day 1–3 4/37 10.8% 3.5–26.4%
Day 4–6 2/18 11.1% 2.0–36.1%
Day 7 2/3 66.7% 12.5–98.2%
Unknownb 2/16 12.5% 2.2–39.6%
Total (MAT) 10/74 13.5% 7.0–24.0%
LEPkit Positive T-line Day 1–3 36/37 97.3% 84.2–99.9%
Day 4–6 18/18 100% 78.1–100%
Day 7 3/3 100% 31.0–100%
Unknownb 16/16 100% 75.9–100%
Total (LEPkit) 73/74 98.7% 91.7–100%

aCriteria for diagnosis of acute leptospirosis at admission-phase by gold standard test included: 1) positive leptospiral isolation by culture; or 2) MAT titer ≥1:400 at admission-phase. bThe disease onset was unclear or was not recorded. 95% CI = 95% confidence interval determined by McNemar’s test.