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. 2017 May 24;8:600. doi: 10.3389/fimmu.2017.00600

Table 1.

Mice with gene-targeted deficiencies for enzymes involved in the synthesis of O-glycans.

Gene Full enzyme name Abbreviated name(s) Function Reference
Gcnt1a Core 2 β1-6 N-acetylglucosaminyltransferase-I C2GlcNAcT-I; C2GnT-I Initial β1-6 GlcNAc for core 2 O-glycans Ellies et al. (15)
Fut7 α1-3 fucosyltransferase VII FutVII; FucTVII Fucosyltransferase for Lewis X synthesis (Major) Maly et al. (16)
Fut4 α1-3 fucosyltransferase IV FutIV; FucTIV Fucosyltransferase for Lewis X synthesis (Minor) Homeister et al. (17)
St3gal4 ST3 β-galactoside α2-3 sialyltransferase IV ST3Gal-IV Sialylation of Lewis X (Major) Ellies et al. (18)
St3gal6 ST3 β-galactoside α2-3 sialyltransferase VI ST3Gal-VI Sialylation of Lewis X (Minor) Yang et al. (19)
B3Gnt3 β1-3 N-acetylglucosaminyltransferase-3 β3GnT-3 Extension of Core 1 O-glycans Yeh et al. (20)
St3Gal1a ST3 β-galactoside α2-3 sialyltransferase-I ST3Gal-I Core 1 sialylation Priatel et al. (21)

aMice with conditional potential available.