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. 2017 May 24;8:570. doi: 10.3389/fimmu.2017.00570

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Copyright © 2017 Keller, Freigang and Lünemann.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Interactions between invariant natural killer T (iNKT) cells and other immune cells. iNKT cells crosstalk with adaptive and innate immune cells including dendritic cells (DCs), B cells, natural killer (NK) cells, myeloid-derived suppressor cells (MDSCs), and conventional T cells. This reciprocal interaction is mediated via T cell receptor (TCR)-CD1d-recognition, interaction of co-stimulatory molecules or cytokines. Additionally, iNKT cells may interact with non-hematopoietic cells that expose signs of infection, transformation, or cell stress.