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Effects of MvfR antagonist 1 on 2-AA and DHQ production in PA14 pqsC mutant with and without external addition of PQS.
| Compounds | Exogenous PQS [μM] | 2-AA IC50 [μM] | DHQ IC50 [μM] | 2-AA + DHQ IC50 [μM] |
|---|---|---|---|---|
| 1 | 0 | 0.05 (0.04-0.06) | 0.03 (0.03-0.04) | 0.03 (0.02-0.04) |
| 1 | 0.33 (0.28-0.38) | 0.09 (0.05-0.18) | 0.11 (0.07-0.19) | |
| 10 | 4.2 (3.0-5.8) | 1.7 (1.3-2.3) | 2.0 (1.4-2.8) | |
The data are reported with 95% Confidence Interval.
