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. 2017 May 17;8:15160. doi: 10.1038/ncomms15160

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Copyright © 2017, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Stage V gametocytes were exposed to the 90 selected compounds for 24 or 48 h to determine the drug inhibitory speed of action. In addition, compounds were added after triggering gametocyte activation to evaluate their activity in female gametes. The figure shows the number of compounds and chemical diversity classified under each category, that is, slow-acting, fast-acting or gamete-targeting compounds.