Figure 9. Folds very similar to VK34 tetramer are adopted also by 2VK34 and 4VK34 oligonucleotides.

Imino and aromatic regions of 1D ¹H NMR and H2′/H2″-aromatic region of 2D NOESY spectrum for (a) VK34 tetramer, (b) 2VK34 fold and (c) 4VK34 fold. The 1D ¹H and 2D NOESY spectra of 2VK34 and 4VK34 folds were recorded at 1.0 mM oligonucleotide and 100 mM LiCl concentrations, 0 °C and pH 6.0. The 1D ¹H and 2D NOESY spectra of tetrameric VK34 fold were recorded at 1.2 mM oligonucleotide and 100 mM NaCl concentrations, 0 °C and pH 6.0. All spectra were recorded with 200 ms mixing times. (d) Tetrameric topology and high-resolution structure of VK34. (e) Dimeric topology and high-resolution structure of 2VK34. (f) Monomeric topology and high-resolution structure of 4VK34. (g) Oligonucleotide sequences of 2VK34 and 4VK34 oligonucleotides.