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. 2017 May 24;7:211. doi: 10.3389/fcimb.2017.00211

Figure 4.

Figure 4

Inflammatory response of pCramoll in combination with fluconazole in Cryptococcus gattii-infected mice, analyzed at 15 and 35 dpi: (A,B) Total and differential count of leukocytes (neutrophils and mononuclear cells) in the bronchoalveolar lavage, respectively; at 15 and 35 days after infection; (C,D) Myeloperoxidase and N-acetylglucosaminidase activities in lungs of infected animals; (E–H) Levels of cytokines IFN-γ, IL-6, IL-10, and IL-17A in lungs. Uninfected animals (NI), infected untreated control (NT), groups treated with pCramoll at 1 μg (pC1), Fluconazole (FCZ), *p < 0.05; **p < 0.01 (difference between treated groups and NT); #p < 0.05 (difference when comparing treated groups); ###p < 0.005 (difference between FCZ alone and combination, at 35 dpi); +p < 0.5 (difference between 15 dpi and 35 dpi). Data represent the means ± SE from three independent experiments consisting of triplicate assays.