Table 4.
ΔLog10 values of the cfu/ml of the Acinetobacter isolates obtained by the time kill curve assays after incubation, as compared to the initial inoculum.
| Antibiotics | Bactericidal effect of colistin and carbapenem alone and in combination (time kill curve) | |||||||
|---|---|---|---|---|---|---|---|---|
| 16xMIC | 8xMIC | 4xMIC | 2xMIC | 1xMIC | 0.5xMIC | 0.25xMIC | 0.125xMIC | |
| ΔLog10 | ||||||||
| Col | 0.429 | 0.155 | 0.214 | 0.441 | 1.18 | 1.368 | 1.621 | 1.826 |
| Imp | 0.325 | 0.139 | 0.137 | 0.121 | 0.218 | 1.12 | 1.914 | 2.174 |
| Mer | 0.413 | 0.131 | 0.116 | 0.282 | 1.12 | 1.922 | 2.054 | 2.194 |
| Col-Imp | 0.437 | 0.196 | 0.115 | 0.066 | 0.096 | 0.349 | 0.915 | 1.828 |
| Col-Mer | 0.403 | 0.178 | 0.098 | 0.195 | 0.106 | 0.815 | 1.06 | 1.802 |
| p-value | 0.528 | 0.698 | 0.679 | 0.103 | 0.831 | 0.018 | 0.112 | 0.731 |
Col, colistin; Imp, Imipenem; Mer, meropenem; Col-Imp, colistin imipenem combination, Col-Mer, Colistin meropenem combination. A ΔLog10 value of ≥ 3 Log10 in cfu/ml determines a bactericidal activity.