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Cytotoxic potency of EGFRvIII/CD3 tandem diabody (TandAb) candidates.
| EGFRvIII-binding Fv in TandAb | Effector binding Fv in TandAb | No. of assays | Cytotoxic potency (EC50) mean of n ≥ 4 (pM) | SD | |
|---|---|---|---|---|---|
| Parental | Li3G30 | CD3x | 10 | 29.8 | ±19.7 |
| Affinity matured | A3 | CD3x | 7 | 4.3 | ±3.3 |
| A4 | CD3x | 4 | 7.4 | ±4.5 | |
| A6 | CD3x | 6 | 3.3 | ±1.3 | |
| A7 | CD3x | 4 | 11.0 | ±2.6 | |
| A8 | CD3x | 4 | 7.2 | ±1.3 | |
| A9 | CD3x | 4 | 5.3 | ±1.9 |
Individual results were measured in FACS-based cytotoxicity assay on CHOEGFRvIII target cells.
