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. 2016 Dec 19;36(19):2737–2749. doi: 10.1038/onc.2016.427

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Copyright © 2017 The Author(s)

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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In vivo assessment of the role of EVI1 and SOX9. (a, b) Depletion of EVI1/Evi11 expression (using two different short hairpin RNAs (shRNAs)) in LM2 and 4T1 cells reduced lung colonization, and Sox9 overexpression partially recovered this potential, left panels. (a) Right panels show representative images of lungs and their respective HE staining. (c) Depletion of SOX9 and overexpression of Sox9 reduced and increased, respectively, lung colonization of LM2 cells. Treatment with everolimus of shControl LM2 cells also reduced lung colonization. (d) Depletion of Sox9 or treatment with everolimus of 4T1 cells reduced lung colonization. (e, f) Depletion of FSCN1/Fscn1 expression in LM2 and 4T1 cells reduced lung colonization, and concurrent treatment with everolimus further impaired this potential.