Figure 3.

Induced expression of genes regulating proliferation occurs due to decreased expression of miRNAs. The relative gene expression of Jak2 (a), Notch2 (b), and Hif1α (c) shows significant upregulation in inflamed colons as compared to both control and uninflamed colons of colitis-induced animals. In contrast, the expression of miR-375 (d), miR-30a (e), and miR-107 (f) is significantly downregulated in inflamed colons. Data are presented as the mean ± SEM; the significance of differences between sets of data was determined by one-way analysis of variance (ANOVA) using SPSS Statistics; ^∗p < 0.05.