Table 3.
Distributions of IL-31 SNPs among cases and controls and their associations with DCM susceptibility.
| Genotype | rs4758680 | Genotype | rs7977932 | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Cases n (%) |
Controls n (%) |
OR (95%CI) | P value | Cases n (%) |
Controls n (%) |
OR (95%CI) | P value | |||
| Model | ||||||||||
| Codominant | CC | 275 (83.1%) | 361 (73.2%) | 1.00 | — | CC | 271 (81.9%) | 401 (81.3%) | 1.00 | — |
| CA | 43 (13.0%) | 114 (23.1%) | 0.50 (0.34–0.72) | 0.001 | CG | 56 (16.9%) | 87 (17.6%) | 1.05 (0.73–1.52) | 0.930 | |
| AA | 13 (3.9%) | 18 (3.6%) | 0.95 (0.46–1.96) | — | GG | 4 (1.2%) | 5 (1.0%) | 0.84 (0.22–3.17) | — | |
|
| ||||||||||
| Dominant | CC | 275 (83.1%) | 361 (73.2%) | 1.00 | — | CC | 271 (81.9%) | 401 (81.3%) | 1.00 | — |
| CA/AA | 56 (16.9%) | 132 (26.8%) | 0.56 (0.39–0.79) | <0.001 | CG/GG | 60 (18.1%) | 92 (18.7%) | 1.04 (0.72–1.49) | 0.850 | |
|
| ||||||||||
| Recessive | CC/CA | 318 (96.1%) | 475 (96.3%) | 1.00 | — | CC/CG | 327 (98.8%) | 488 (99.0%) | 1.00 | — |
| AA | 13 (3.9%) | 18 (3.6%) | 0.93 (0.45–1.92) | 0.840 | GG | 4 (1.2%) | 5 (1.0%) | 0.84 (0.22–3.14) | 0.790 | |
|
| ||||||||||
| Overdominant | CC/AA | 288 (87.0%) | 379 (76.9%) | 1.00 | — | CC/GG | 275 (83.1%) | 406 (82.4%) | 1.00 | — |
| CA | 43 (13.0%) | 114 (23.1%) | 0.50 (0.34–0.73) | <0.001 | CG | 56 (16.9%) | 87 (17.6%) | 1.05 (0.73–1.52) | 0.790 | |
| Allele | Allele | |||||||||
| C | 593 (89.6%) | 836 (84.8%) | 1.00 | — | C | 598 (90.3%) | 889 (90.2%) | 1.00 | — | |
| A | 69 (10.4%) | 150 (15.2%) | 0.65 (0.48–0.88) | 0.005 | G | 64 (9.7%) | 97 (9.8%) | 1.02 (0.73–1.42) | 0.909 | |
OR: odds ratio; CI: confidence interval; SNP analysis adjusted for age, gender, LVEDD, and LVEF.