Table 5.
Associations between IL-31 SNPs and patients' overall survival.
| Characteristics | Genotype | Overall survival | |||||
|---|---|---|---|---|---|---|---|
| Multivariate survival analysisa | Univariate survival analysis | ||||||
| HR | 95%CI | P value | HR | 95%CI | P value | ||
| Model | |||||||
| rs4758680 | |||||||
| Dominant | CC | 1 | — | — | 1 | — | — |
| CA/AA | 0.548 | 0.345–0.869 | 0.011 | 0.530 | 0.337–0.834 | 0.006 | |
| Recessive | CC/CA | 1 | — | — | 1 | — | — |
| AA | 0.868 | 0.399–1.888 | 0.722 | 0.778 | 0.361–1.678 | 0.522 | |
| Overdominant | CC/AA | 1 | — | — | 1 | — | — |
| CA | 0.503 | 0.297–0.852 | 0.011 | 0.516 | 0.310–0.861 | 0.011 | |
| rs7977932 | |||||||
| Dominant | CC | 1 | — | — | 1 | — | — |
| CG/GG | 1.161 | 0.666–2.024 | 0.599 | 1.275 | 0.736–2.211 | 0.386 | |
| Recessive | CC/CG | 1 | — | — | 1 | — | — |
| GG | 3.739 | 0.862–16.218 | 0.078 | 3.482 | 0.841–14.414 | 0.085 | |
| Overdominant | CC/GG | 1 | — | — | 1 | — | — |
| CG | 1.096 | 0.619–1.943 | 0.753 | 1.211 | 0.687–2.133 | 0.508 | |
aMultivariate survival analysis adjusted for age, gender, LVEDD, and LVEF.