Table 3.
Cox proportional hazard regression analysis of patients' overall survival.
| Variables | Univariable | Multivariable | ||||
|---|---|---|---|---|---|---|
| Hazard ratio | 95% CI | p value | Hazard ratio | 95% CI | p value | |
| Gender (female versus male) | 0.785 | 0.493–1.332 | 0.407 | — | — | — |
| Age (<50 versus ≥50) | 0.551 | 0.316–0.830 | 0.004∗ | 0.608 | 0.331–1.111 | 0.106 |
| AFP (≥400 ng/mL versus <400 ng/mL) | 1.608 | 1.124–2.300 | 0.009∗ | 1.657 | 1.149–2.387 | 0.007∗ |
| ALT (>80 IU/L versus ≤80 IU/L) | 1.473 | 1.016–2.135 | 0.041∗ | 1.299 | 0.952–2.113 | 0.541 |
| Albumin (>35 g/L versus ≤35 g/L) | 0.327 | 0.540–1.228 | 0.327 | — | — | — |
| Bilirubin (>20 μmol/L versus ≤20 μmol/L) | 1.380 | 0.747–2.551 | 0.304 | — | — | — |
| Number of tumor lesions (single versus multiple) | 0.438 | 0.296–0.648 | 0.000∗ | 0.482 | 0.297–0.783 | 0.003∗ |
| Vascular invasion (absent versus present) | 0.468 | 0.307–0.712 | 0.006∗ | 0.476 | 0.277–0.819 | 0.007∗ |
| Cirrhosis (absent versus present) | 0.553 | 0.385–0.792 | 0.001∗ | 0.543 | 0.370–0.797 | 0.002∗ |
| Histological differentiation | ||||||
| Moderately versus well | 1.146 | 0.674–1.948 | 0.614 | — | — | — |
| Poorly versus well | 1.593 | 0.840–3.020 | 0.153 | — | — | — |
| Greatest tumor diameter | ||||||
| (≥5 cm versus <5 cm) | 1.619 | 1.012–2.591 | 0.044∗ | 1.422 | 0.976–2.074 | 0.067 |
| EpCAM (positive versus negative) | 2.053 | 1.272–3.313 | 0.003∗ | 2.030 | 1.252–3.290 | 0.004∗ |
| CD13 (positive versus negative) | 1.625 | 1.022–2.502 | 0.040∗ | 1.469 | 0.908–2.378 | 0.117 |
CI: confidence interval; AFP: alpha-fetoprotein; ALT: alanine aminotransferase; ∗ indicates p < 0.05.