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. Author manuscript; available in PMC: 2017 Dec 7.

Published in final edited form as: J Am Chem Soc. 2016 Nov 21;138(48):15682–15689. doi: 10.1021/jacs.6b09511

Changes in backbone solvation do not correlate with ΔΔG°. The difference in the number of water molecules blocked by D-Ala relative to Gly (Unfolded-folded) is plotted vs (A) calculated ΔΔG° values (r=0.16). (B) experimental ΔΔG° values (r=0.17). EH ●; GA ; HP35 ; NTL9 ; PSBD ▲; Trp-cage ; UBA ; Ubiquitin ■. Positive ΔΔG° values indicate stabilization.

Inline graphic — Changes in backbone solvation do not correlate with ΔΔG°. The difference in the number of water molecules blocked by D-Ala relative to Gly (Unfolded-folded) is plotted vs (A) calculated ΔΔG° values (r=0.16). (B) experimental ΔΔG° values (r=0.17). EH ●; GA ; HP35 ; NTL9 ; PSBD ▲; Trp-cage ; UBA ; Ubiquitin ■. Positive ΔΔG° values indicate stabilization.