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. 2017 Mar 17;24(6):997–1006. doi: 10.1038/cdd.2017.31

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Copyright © 2017 The Author(s)

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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Th1 cells accelerate the proliferation of HSCs through the IFN-γ/STAT1 pathway and this impact is attenuated by Tregs. (a) HSCs were stimulated with supernatants or cells of Th1 or Treg from BA for 24 h, with or without pretreatment of IFN-γR siRNA or STAT1 siRNA for 12 h. NC, normal control; Th1+Treg supernatants, supernatants from Th1 cells prestimulated with Tregs; Th1+Treg cells, Th1 cells prestimulated with Tregs. (b) Quantification of cell proliferative assay at 24 and 48 h. Values are means±S.D. of 12 independent experiments assayed in duplicate. (*P<0.05; **P<0.01). (c) Left panel: HSCs were transfected with its specific siRNAs (siSTAT1 or siIFN-γR) following treatment with various concentrations of rIFN-γ for 24 h. Right panel: quantification of cell proliferative assay at 24 h