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. 2017 May 5;24(6):1121–1131. doi: 10.1038/cdd.2017.62

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Establishment of a permissive chromatin state in the promoter regions. (a) Statistics summary of each category of promoters defined by histone modification mark(s) in hESCs changing into other categories in hNECs. (b) Changes in expression levels of genes with H3K4me3/H3K9ac in hESCs upon differentiation to hNECs. Gain of repressive H3K27me3 is associated with decreased expression. (c) Fold change of core histone modification signals in the promoters with NDR formation upon differentiation. (d) Increased H3K36me3 signals and RNA Pol II binding in the genes with NDR formation in the promoters upon differentiation