TABLE 2.
Imipenem MIC frequency distributions against carbapenemase-positive isolates of K. pneumoniae, E. coli, and E. cloacae stratified by carbapenemase type
| Organism or genotypea (no. of isolates) | No. (%) of isolates with indicated imipenem MIC (μg/ml)b |
|||||||
|---|---|---|---|---|---|---|---|---|
| 0.12 | 0.25 | 0.5 | 1 | 2 | 4 | 8 | >8 | |
| K. pneumoniae (1,127) | 1 (0.1) | 5 (0.4) | 16 (1.4) | 59 (5.2) | 138 (12.2) | 146 (13.0) | 170 (15.1) | 592 (52.5) |
| KPC (682) | 1 (0.1) | 7 (1.0) | 39 (5.7) | 83 (12.2) | 117 (17.2) | 435 (63.8) | ||
| OXA-48-like (217) | 1 (0.5) | 4 (1.8) | 14 (6.5) | 49 (22.6) | 82 (37.8) | 36 (16.6) | 12 (5.5) | 19 (8.8) |
| NDM (169) | 13 (7.7) | 29 (17.2) | 127 (75.1) | |||||
| VIM (52) | 4 (7.7) | 11 (21.2) | 11 (21.2) | 26 (50.0) | ||||
| IMP (24) | 1 (4.2) | 1 (4.2) | 2 (8.3) | 13 (54.2) | 3 (12.5) | 2 (8.3) | 2 (8.3) | |
| GES (2) | 2 (100) | |||||||
| E. coli (149) | 1 (0.7) | 5 (3.4) | 6 (4.0) | 20 (13.4) | 31 (20.8) | 21 (14.1) | 29 (19.5) | 36 (24.2) |
| KPC (42) | 1 (2.4) | 3 (7.1) | 16 (38.1) | 7 (16.7) | 5 (11.9) | 10 (23.8) | ||
| OXA-48-like (46) | 5 (10.9) | 5 (10.9) | 17 (37.0) | 13 (28.3) | 4 (8.7) | 2 (4.3) | ||
| NDM (57) | 1 (1.8) | 7 (12.3) | 24 (42.1) | 25 (43.9) | ||||
| VIM (2) | 1 (50.0) | 1 (50.0) | ||||||
| IMP (3) | 1 (33.3) | 2 (66.7) | ||||||
| GES (0) | ||||||||
| E. cloacae (110) | 1 (0.9) | 4 (3.6) | 9 (8.2) | 17 (15.5) | 22 (20.0) | 29 (26.4) | 28 (25.5) | |
| KPC (22) | 2 (9.1) | 2 (9.1) | 3 (13.6) | 9 (40.9) | 6 (27.3) | |||
| OXA-48-like (16) | 1 (6.3) | 2 (12.5) | 3 (18.8) | 5 (31.3) | 2 (12.5) | 3 (18.8) | ||
| NDM (40) | 1 (2.5) | 7 (17.5) | 10 (25.0) | 22 (55.0) | ||||
| VIM (28) | 3 (10.7) | 5 (17.9) | 10 (35.7) | 10 (35.7) | ||||
| IMP (9) | 2 (22.2) | 1 (11.1) | 4 (44.4) | 1 (11.1) | 1 (11.1) | |||
| GES (0) | ||||||||
a
Data include 7 ertapenem-susceptible isolates (K. pneumoniae, 4 isolates; E. coli, 3 isolates).
b
Imipenem MIC breakpoints: susceptible, ≤1μg/ml (gray shading); intermediate, 2 μg/ml; resistant, ≥4 μg/ml (11).