TABLE 3.
Activity of antimicrobial agents against carbapenemase-positive isolates of Enterobacteriaceae collected by the SMART global surveillance program from 2008 to 2014
| Genotype/phenotype (no. of isolates) | Antimicrobial agent | MIC50 (μg/ml) | MIC90 (μg/ml) | MIC range (μg/ml) | % susceptible |
|---|---|---|---|---|---|
| All carbapenemase-positive isolates (1,493) | Ertapenem | >4 | >4 | <0.03 to >4 | 0.5 |
| Imipenem | 8 | >8 | 0.12 to >8 | 9.4 | |
| Cefepime | >32 | >32 | <0.5 to >32 | 5.8 | |
| Ceftriaxone | >32 | >32 | <1 to >32 | 3.1 | |
| Cefotaxime | >128 | >128 | <0.5 to >128 | 2.3 | |
| Ceftazidime | >128 | >128 | <0.5 to >128 | 7.9 | |
| Cefoxitin | >16 | >16 | <2 to >16 | 12.7 | |
| Ampicillin-sulbactam | >16 | >16 | <2 to >16 | 0.1 | |
| Piperacillin-tazobactam | >64 | >64 | <2 to >64 | 1.6 | |
| Ciprofloxacin | >2 | >2 | <0.25 to >2 | 10.0 | |
| Levofloxacin | >4 | >4 | <0.5 to >4 | 16.8 | |
| Amikacin | 32 | >32 | <4 to >32 | 49.8 | |
| Carbapenemase-positive imipenem-nonsusceptible isolates (1,352) | Ertapenem | >4 | >4 | <0.03 to >4 | 0.2 |
| Imipenem | >8 | >8 | 2 to >8 | 0 | |
| Cefepime | >32 | >32 | <0.5 to >32 | 4.0 | |
| Ceftriaxone | >32 | >32 | <1 to >32 | 1.6 | |
| Cefotaxime | >128 | >128 | <0.5 to >128 | 1.1 | |
| Ceftazidime | >128 | >128 | <0.5 to >128 | 6.0 | |
| Cefoxitin | >16 | >16 | <2 to >16 | 9.4 | |
| Ampicillin-sulbactam | >16 | >16 | <2 to >16 | 0.1 | |
| Piperacillin-tazobactam | >64 | >64 | <2 to >64 | 1.0 | |
| Ciprofloxacin | >2 | >2 | <0.25 to >2 | 8.7 | |
| Levofloxacin | >4 | >4 | <0.5 to >4 | 15.0 | |
| Amikacin | 32 | >32 | <4 to >32 | 46.5 | |
| Carbapenemase-positive imipenem-susceptible isolates (141) | Ertapenem | 2 | >4 | <0.03 to >4 | 3.5 |
| Imipenem | 1 | 1 | 0.12 to 1 | 100 | |
| Cefepime | >32 | >32 | <0.5 to >32 | 23.4 | |
| Ceftriaxone | >32 | >32 | <1 to >32 | 17.7 | |
| Cefotaxime | >128 | >128 | <0.5 to >128 | 14.2 | |
| Ceftazidime | 64 | >128 | <0.5 to >128 | 26.2 | |
| Cefoxitin | 16 | >16 | <2 to >16 | 44.7 | |
| Ampicillin-sulbactam | >16 | >16 | 16 to >16 | 0 | |
| Piperacillin-tazobactam | >64 | >64 | <2 to >64 | 7.8 | |
| Ciprofloxacin | >2 | >2 | <0.25 to >2 | 23.4 | |
| Levofloxacin | >4 | >4 | <0.5 to >4 | 34.0 | |
| Amikacin | <4 | >32 | <4 to >32 | 80.9 |