TABLE 1.
Associations between baseline clinical characteristics and patient mortality by 52-week follow-up period for patients with complete sequencing data for at least one gene of interest (n = 451)
| Characteristic or parameter | No. of patients | No. deceased | % deceased | OR (95% CI)a |
|
|---|---|---|---|---|---|
| Unadjusted | Adjusted | ||||
| Total no. of patients | 451 | 88 | 19.5 | ||
| Sex | |||||
| Female | 155 | 31 | 20.0 | 1.00 | 1.00 |
| Male | 296 | 57 | 19.3 | 0.95 (0.59–1.55) | 1.37 (0.78–2.42) |
| Age (yrs) | |||||
| <25 | 90 | 20 | 22.2 | 1.00 | 1.00 |
| 25 to 49 | 271 | 54 | 19.9 | 0.87 (0.49–1.55) | 1.12 (0.58–2.15) |
| ≥50 | 90 | 14 | 15.6 | 0.64 (0.30–1.37) | 1.19 (0.49–2.86) |
| BMI | |||||
| <18.50 | 210 | 57 | 27.1 | 1.00 | 1.00 |
| 18.50 to <25 | 212 | 25 | 11.8 | 0.36 (0.21–0.60)** | 0.40 (0.23–0.69)** |
| ≥25 | 29 | 6 | 20.7 | 0.70 (0.27–1.81) | 0.88 (0.30–2.54) |
| Smoked in previous 3 mo | |||||
| No | 314 | 69 | 22.0 | 1.00 | 1.00 |
| Yes | 137 | 19 | 13.9 | 0.57 (0.33–0.99)* | 1.07 (0.53–2.18) |
| TB treatment | |||||
| New | 135 | 14 | 10.4 | 1.00 | 1.00 |
| Previously treated | 316 | 74 | 23.4 | 2.64 (1.43–4.87)** | 1.24 (0.49–3.12) |
| Site | |||||
| Moldova | 164 | 17 | 10.4 | 1.00 | 1.00 |
| India | 165 | 47 | 28.5 | 3.44 (1.88–6.31)** | 2.81 (1.06–7.47)* |
| South Africa | 122 | 24 | 19.7 | 2.12 (1.08–4.15)* | 0.92 (0.32–2.68) |
| Diabetes | |||||
| No | 430 | 83 | 19.3 | 1.00 | 1.00 |
| Yes | 21 | 5 | 23.8 | 1.31 (0.47–3.67) | 1.43 (0.45–4.50) |
| HIV positive | |||||
| No | 383 | 68 | 17.8 | 1.00 | 1.00 |
| Yes | 68 | 20 | 29.4 | 1.93 (1.08–3.46)* | 2.76 (1.22–6.28)* |
a
The adjusted model is adjusted for all other variables. *, P ≤ 0.05; **, P ≤ 0.01. Bolded text indicates statistically significant findings.