Figure 1:

Renal function effect on ART-123 plasma concentrations during the first 24 hours. The plasma concentrations of ART-123 are presented as mean ± standard deviation. No relevant differences in the ART-123 plasma concentrations were observed among patients with different levels of renal function. Regardless of patient renal function, the plasma concentrations of ART-123 in disseminated intravascular coagulation (DIC) patients administered 380 U/kg of ART-123 were higher than those in the DIC patients administered 130 U/kg of ART-123.