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Relationship between 24-h creatinine clearance and urinary excretion rate of ART-123 on Day 1. The urinary excretion rate of ART-123 correlated closely with 24-h creatinine clearance. Urinary excretion rate of ART-123 was calculated by dividing the amount of ART-123 in urine excreted during 24 h after dosing by the amount of initially administered dose.
