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Relationship between 24-h creatinine clearance and total body clearance of ART-123 on Day 1. Total body clearance decreased in patients with decreased creatinine clearance (r = 0.526). However, the total body clearance in patients with creatinine clearance < 30 ml/min did not decrease. Although some patients received continuous renal replacement therapy (CRRT), it did not affect ART-123 clearance. ○ : CRRT was not performed, • : CRRT was performed. CLtot, total body clearance.
