Table 1:
Patient characteristics.
| Dose | 380 U/kg | 130 U/kg | ||||||
|---|---|---|---|---|---|---|---|---|
| Group 1 | Group 2 | Group 3 | Group 4 | Group 1 | Group 2 | Group 3 | Group 4 | |
| Ccr < 10.0 | 10.0 ≤ Ccr < 30.0 | 30.0 ≤ Ccr < 60.0 | 60.0 ≤ Ccr | Ccr < 10.0 | 10.0 ≤ Ccr < 30.0 | 30.0 ≤ Ccr < 60.0 | 60.0 ≤ Ccr | |
| Number of patients | 9 | 6 | 6 | 10 | 4 | 3 | 0 | 1 |
| Ccr (ml/min), minimum – maximum (mean) | 0.0–9.9 (5.6) | 13.6–23.2 (18.1) | 35.3–55.1 (47.9) | 60.5–97.4 (78.4) | 0.4–5.4 (3.3) | 11.7–26.9 (20.5) | - | 92.3–92.3 (92.3) |
| Age (years), mean ± SD | 72.1 ± 10.3 | 63.7 ± 20.8 | 71.7 ± 13.3 | 72.6 ± 12.6 | 74.3 ± 8.7 | 78.7 ± 5.1 | - | 64.0 |
| Sex, male/female | 9/0 | 1/5 | 2/4 | 2/8 | 4/0 | 2/1 | - | 1/0 |
| Weight (kg), mean ± SD | 58.67 ± 7.50 | 55.02 ± 9.65 | 60.77 ± 19.92 | 51.85 ± 12.06 | 63.50 ± 12.06 | 72.13 ± 21.09 | - | 70.90 |
| BMI (kg/m2), mean ± SD | 21.44 ± 2.65 | 23.27 ± 5.29 | 24.73 ± 4.68 | 22.14 ± 4.36 | 23.99 ± 5.42 | 28.50 ± 7.91 | - | 25.12 |
| APACHE II score, mean ± SD | 21.6 ± 6.8 | 16.0 ± 7.3 | 22.3 ± 3.9 | 15.4 ± 4.5 | 24.5 ± 9.2 | 22.0 ± 9.6 | - | 8.0 |
| DIC score, mean ± SD | 5.3 ± 1.1 | 4.8 ± 1.6 | 5.8 ± 1.0 | 5.1 ± 1.3 | 5.8 ± 1.7 | 5.3 ± 2.3 | - | 4.0 |
| SOFA score, mean ± SD | 13.3 ± 2.5 | 9.7 ± 1.5 | 9.5 ± 2.2 | 7.7 ± 2.6 | 13.0 ± 3.6 | 11.3 ± 2.1 | - | 12.0 |
| CRRT, Presence/absence | 8/1 | 1/5 | 2/4 | 0/10 | 2/2 | 1/2 | - | 0/1 |
| Underlying diseases that directly induced DIC, n | ||||||||
| Infectious disease | 9 | 6 | 5 | 8 | 4 | 2 | 0 | 1 |
| Respiratory | 3 | 2 | 2 | 0 | 2 | 0 | 0 | 0 |
| Abdominal organs | 4 | 0 | 1 | 1 | 0 | 1 | 0 | 1 |
| Urinary/ Reproductive organs | 1 | 1 | 2 | 4 | 1 | 0 | 0 | 0 |
| Soft tissue | 0 | 2 | 0 | 3 | 0 | 0 | 0 | 0 |
| Others | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 0 |
| Non infectious | 0 | 0 | 1 | 2 | 0 | 1 | 0 | 0 |
Ccr, 24-hour creatinine clearance on Day 1; BMI, body mass index; APACHE, Acute Physiology and Chronic Health Evaluation; DIC, disseminated intravascular coagulation; SOFA, Sequential Organ Failure Assessment; CRRT, continuous renal replacement therapy.