. 2017 May 23;18:101. doi: 10.1186/s12931-017-0585-y

Table 1.

Physiological parameters

	Baseline	P0	P20	P15	P10	P5
MAP [mmHg]	82 ± 8	81 ± 17	69 ± 12^{a, b}	76 ± 13	75 ± 12	74 ± 12
CVP [mmHg]	7 ± 1	6 ± 2	9 ± 2	9 ± 2	8 ± 2	6 ± 2
MPAP [mmHg]	17 ± 2	35 ± 5^a	32 ± 5^a	29 ± 6^a	30 ± 9^a	28 ± 6^a
CO [l min⁻¹]	3.8 ± 0.6^{b, c}	5.2 ± 1.6	3.7 ± 0.9^{b, c}	3.8 ± 0.8^{b, c}	4.2 ± 1.0^c	5.6 ± 1.5
EVLWI [ml kg⁻¹]	13 ± 4	25 ± 10^a	22 ± 9^a	22 ± 9^a	23 ± 9^a	24 ± 10^a
V_t [ml kg⁻¹]	6.6 ± 0.4	6.9 ± 0.4	6.9 ± 0.5	6.9 ± 0.4	6.9 ± 0.4	7.0 ± 0.4
RR [min⁻¹]	36 ± 4	35 ± 3	44 ± 3^{a, b}	44 ± 3^{a, b}	43 ± 3^{a, b}	41 ± 4^{a, b}
etCO₂ [mmHg]	39 ± 2	40 ± 6^c	46 ± 4^{a, b, d, c}	42 ± 3^{d, c}	38 ± 2	36 ± 3
P_peak [cmH₂O]	15 ± 2	29 ± 8^a	40 ± 3^{a, b, e, d, c}	32 ± 4^a	29 ± 6^a	28 ± 7^a
PEEP [cmH₂O]	5 ± 1	1 ± 1^{a, e, d, c}	21 ± 1^{a, b, e, d, c}	16 ± 1^{a, d, c}	10 ± 1^{a, c}	5 ± 1
P_TP [cmH₂O]	5 ± 3	18 ± 6^a	25 ± 3^{a, b, e, d, c}	19 ± 4^a	17 ± 6^a	17 ± 9^a
∆P [cmH₂O]	8 ± 2	25 ± 5^{a, e, c}	18 ± 3^{a, b}	15 ± 4^a	18 ± 7^a	22 ± 7^{a, e, d}
C_dyn [ml cmH₂O⁻¹]	22 ± 7	8 ± 2^a	12 ± 3^{a, b}	14 ± 4^{a, b, c}	13 ± 5^{a, b}	10 ± 3^a

MAP mean arterial pressure, CVP central venous pressure, MPAP mean pulmonal arterial pressure, CO cardiac output, EVLWI extravascular lung water index, V _t tidaL volume, RR respiratory rate, etCO ₂ endtidal carbon dioxide, P _peak peak inspiratory pressure, PEEP positive endexpiratory pressure, P _TP transpulmonary pressure, ∆P dynamically calculated airway driving pressure (P_peak-PEEP), C _dyn dynamic lung compliance

P < 0.05

^a vs. BLH

^b vs. P0

^c vs. P5

^d vs. P10

^e vs P15