Table 1.
Patient characteristics on admission
| Placebo, N = 10 | Rosiglitazone, N = 20 | p | |
|---|---|---|---|
| Female sex (%) | 7 (70%) | 11 (55%) | 0.70 |
| Age (years)a | 8 (4.6, 9.1) | 6.9 (4.7, 9.8) | 0.92 |
| Weight (kg) | 21.5 [15.0, 24.8] | 20.2 [16.1, 2.7] | 0.87 |
| Height (cm) | 124.0 [101.0, 132.5] | 115.0 [106.0, 131.5] | 0.75 |
| BMI/age | −1.13 [−1.40, −0.37] | −0.15 [−3.2, 0.24] | 0.11 |
| Weight-for-age Z score (WAZ) | −1.1 [−1.4, −0.73] | −0.67 [−1.5, 0.81] | 0.34 |
| Temperature (oC) | 38.3 [36.6, 39.1] | 36.6 [36.1, 37.5] | 0.07 |
| Heart rate (bpm) | 123.2 (15.58) | 120.1 (14.6) | 0.60 |
| Glucose (mmol/L) | 7.2 [5.3, 8.3] | 5.9 [5.1, 7.3] | 0.40 |
| Lactate (mmol/L) | 2.5 [2.1, 2.9] | 1.9 [1.8, 3.2] | 0.23 |
| Haemoglobin (g/L) | 10.1 (0.8) | 10.1 (1.5) | 0.99 |
| Haematocrit (%) | 30.1 (2.3) | 30.4 (4.0) | 0.83 |
| Leukocytes (×109/L) | 8.3 (3.0) | 7.4 (2.5) | 0.41 |
| Platelets (×109/L) | 96.3 (34.3) | 131.8 (59.4) | 0.09 |
| AST (U/L) | 53.8 (41.7) | 36.4 (10.5) | 0.08 |
| ALT (U/L) | 27.5 [5.3, 41.0] | 33 [26, 36.8] | 0.54 |
| Urea (mg/dL) | 12.5 [12.0, 17.3] | 14.0 [13.0, 15.8] | 0.67 |
| Creatinine (µmol/L) | 35.3 [30.7, 39.0] | 31.2 [29.8, 42.8] | 0.81 |
| Parasite density (parasites/μL) | 23,499 {4166, 55,491} | 24,622 {3346, 91,869} | 0.91 |
Median [IQR] for non-normally distributed variables
Number (%) for categorical variables
Parasite density is represented as geometric mean {range}
aMean (SD) for normally distributed variables