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. 2016 Aug 18;6(1):110–120. doi: 10.5966/sctm.2016-0083

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© 2016 The Authors Stem Cells Translational Medicine published by Wiley Periodicals, Inc. on behalf of AlphaMed Press

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Transcript levels and localization of differentiation markers in tissue, 2D, and peptide‐modified 3D hyaluronate (HA) hydrogels. (A): Levels of acinar and ductal differentiation markers are significantly lower among human stem/progenitor cells grown in 2D and 3D peptide‐modified HA hydrogels compared with the whole hPG tissue. Error bars represent SEM. Statistical analysis was performed using one‐way analysis of variance followed by the Tukey‐Kramer test; ∗, p < .05. (B): Localization of MIST1/BHLHA15 and amylase in hPG tissue and 2D and 3D HA hydrogels with basement membrane‐derived peptides. Scale bar = 20 μm. Abbreviations: 2D, two‐dimensional; 3D, three‐dimensional; hPG, human parotid gland.