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. 2016 Aug 8;6(1):316–329. doi: 10.5966/sctm.2016-0087

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© 2016 The Authors Stem Cells Translational Medicine published by Wiley Periodicals, Inc. on behalf of AlphaMed Press

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Schematic representation of mice distribution in different groups. Group 1 (5 mice) was used for isolation of stem cells from bone marrow; group 2 (6 mice) was utilized for IHC to confirm stem cell homing. Three mice were sacrificed on D3, and 3 on D7, after MSCs transplantation; group 3 (20 mice) was assigned for simultaneous MRI (T2* and ADC) and brain water content measurement at 5 time points (4 mice per time point); group 4 (20 mice) was investigated for longitudinal in vivo 1H‐MRS study in before injury, after injury, and at different time points after MSCs transplantation in the same mice. Ten mice from this group participated in the behavioral test after final 1H‐MRS study; group 5 (30 mice) was divided into 3 groups (control, injury, and stem cell‐transplanted control groups) to assess behavioral changes with the behavioral test. Abbreviations: ADC, apparent diffusion coefficient; D, day; IHC, immunohistochemistry; 1H‐MRS, proton magnetic resonance spectroscopy; MRI, magnetic resonance imagining; MSC, mesenchymal stem cell; TBI; traumatic brain injury.