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. 2016 Oct 7;6(3):830–839. doi: 10.5966/sctm.2016-0009

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© 2016 The Authors Stem Cells Translational Medicine published by Wiley Periodicals, Inc. on behalf of AlphaMed Press

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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bELE synergistically sensitizes both parental glioma cell lines and induced GSLCs to TMZ. (A, B): bELE (2.5 μg/ml) promoted the inhibition effect of TMZ on both parental glioma cell lines (U87, U373, SHG‐44, T98G, and SKMG‐4) and induced GSLCs (U87/GSLC, U373/GSLC, SHG‐44/GSLC, T98G/GSLC, and SKMG‐4/GSLC). (C): The combination index of bELE (2.5 μg/ml) and TMZ in induced GSLCs (U87/GSLC, U373/GSLC, SHG‐44/GSLC, T98G/GSLC, and SKMG‐4/GSLC). ∗, p < .05; ∗∗, p < .01; ∗∗∗, p < .001; n = 4. Abbreviations: bELE, β‐elemene; GSLCs, glioma stem‐like cells; TMZ, temozolomide.