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. 2016 Oct 5;6(3):689–699. doi: 10.5966/sctm.2016-0237

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© 2016 The Authors Stem Cells Translational Medicine published by Wiley Periodicals, Inc. on behalf of AlphaMed Press

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Stempeucel treatment ameliorates ischemia‐induced limb necrosis and limb salvage in mice. (A): Representative photographs of sham control (Aa, Ad), vehicle‐treated limb ischemia (Ab, Ae), and Stempeucel‐treated (Ac, Af) LI on day 7 and day 28 after cell treatment. Stempeucel treatment significantly improved limb salvage in comparison with vehicle. (Ba, Bb, Bc): Hematoxylin and eosin‐stained sections of adductor muscle show severe necrosis (yellow arrows) and infiltration of inflammatory cells (green arrows), which were markedly reduced in the Stempeucel‐treated animals (Bc). Original magnification, ×40; scale bars = 50 µm. Abbreviation: LI, limb ischemia.