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. 2016 Oct 14;6(3):761–766. doi: 10.5966/sctm.2016-0175

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© 2016 The Authors Stem Cells Translational Medicine published by Wiley Periodicals, Inc. on behalf of AlphaMed Press

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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HTCECs express CXCR4 and migrate in response to CXCL12. Representative images of immunohistochemistry analysis for CXCR4 expression in HTCECs (n = 3). Expression of CXCR4 in HTCEC side population (A) and non‐side population (B). White arrows, positive cells; blue, 4′,6‐diamidino‐2‐phenylindole; green, fluorescein isothiocyanate‐conjugated secondary anti‐mouse antibody; scale bars = 20 µm). (C): Mean number of migrant cells per HPF from three biological replicates for CXCL12‐mediated migration unsorted HTCECs in comparison with background migration (control). Treatment with CXCL12 ligand was at 300 nM for 5 hours. ∗, Difference in mean values between control and CXCL12‐treated group. Abbreviation: HPF, high‐power field; HTCEC, human telomerase‐immortalized corneal epithelial cell.