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. 2016 Sep 22;6(3):877–885. doi: 10.5966/sctm.2016-0269

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© 2016 The Authors Stem Cells Translational Medicine published by Wiley Periodicals, Inc. on behalf of AlphaMed Press

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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ClearPoint system used for interventional magnetic resonance imaging (iMRI)‐guided transplantation of neural stem cells. (A): The ClearPoint is a frameless navigation system that uses fiducials (white arrow) placed on a head‐mounted aiming device. The system includes the SmartFrame trajectory guide (A), which is hand controlled to rotate and align the cannula guide using initially the blue (pitch; blue arrows) and orange (roll; orange arrows) knobs, followed by the yellow (X; yellow arrows) and green (Y; green arrows) knobs for the final fine adjustments. (B): Head‐fixation frame. (C): Three‐dimensional (3D) surface rendering of a representative baboon head positioned in the head‐fixation frame locked to the MRI table. The surface rendering was constructed from a postinjection MRI series using the “build surface” feature in the software Mango. The 3D surface was smoothed and overlaid with the original MRI slices at the cut planes corresponding to the injection site. Abbreviation: MR, magnetic resonance.