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. 2016 Sep 7;6(2):458–470. doi: 10.5966/sctm.2016-0177

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© 2016 The Authors Stem Cells Translational Medicine published by Wiley Periodicals, Inc. on behalf of AlphaMed Press

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Effects of GMSC/iNPC transplantation on the expression of c‐Jun and Krox‐20/EGR2 in damaged sciatic nerves. At different time points after nerve injury and cell transplantation, sciatic nerves were harvested and tissue lysates were prepared for Western blot analysis. (A–D): Transplantation of GMSCs and iNPCs suppressed injury‐triggered upregulation of c‐Jun protein within 7 days after injury. (E–H): Effects of GMSC and iNPC transplantation on the expression of Krox‐20/EGR2 and the myelin protein P0. (I): Graphs show dynamic changes in the expression of c‐Jun protein summarized from Western blot analysis in Fig. 6A–6D. (J,K): Graphs show dynamic changes in the expression of P0 (J) and Krox‐20/EGR2 (K) proteins summarized from Western blot analysis in Fig. 6E–6H. ∗∗∗, p < .001; ∗∗, p < .01; ∗, p < .05; #, not significant. Abbreviations: Con, control; GMSC, gingiva‐derived mesenchymal stem cell; iNPC, induced neural progenitor‐like cell.