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Proposed clinical positioning of anticancer stem cell‐directed treatments. Most oncologic patients will show a response to first‐line treatment; however, if the cancer stem cell compartment is left untouched, resilient cancer stem cells could fuel new tumor growth later on. Therefore, if the cancer stem cell compartment can be controlled after the first line of treatment, relapses and metastases might be prevented. Abbreviation: CSC, cancer stem cell.
