Figure 3.

Intramuscularly implanted human placental stromal cells (hPSCs) survive and elicit an immune response. At 28 days after intramuscular implantation, numerous hPSCs were detected in the recipient muscles by HLA‐ABC immunostaining (A, B). A significant immune response was evident in proximity to the graft, as manifested by extensive infiltration of CD3⁺ T cells (C, D) and Iba1+ macrophages (E, F). Insets in (A, C, E) are magnified in (B, D, F), respectively; n = 5) in (C). Scale bars = 100 µm (A–C) and 20 µm (D–F). Abbreviations: DAPI, 4′,6‐diamidino‐2‐phenylindole; HLA, human leukocyte antigen.