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. 2016 Sep 29;6(4):1286–1294. doi: 10.5966/sctm.2015-0363

Figure 7.

Figure 7

Intramuscular hPSC implantation before EAE induction did not reduce systemic LNC response. To assess whether hPSC i.m. injection before the onset of clinical signs attenuated the systemic immune response, a proliferative BrdU incorporation assay was conducted on LNCs excised on day 10 after EAE induction. Both ConA and MOG peptide stimulation caused a similar proliferative response in the control and hPSC‐injected mice (A). Also, no difference was detected in the fraction of CD4+, CD25+, Fox3+ regulatory T cells from the lymph nodes and spleen of hPSC‐treated and control groups (n = 6 per group). Abbreviations: BrdU, bromodeoxyuridine; conA, concanavalin A; hPSC, human placental stromal cell; LN, lymph node; MOG, myelin oligodendrocyte glycoprotein; Spl, spleen; Treg, regulatory T cells; treat., treated.