Figure 2.

(See prior page) MSCs modulate monocyte subsets in the blood of coxsackievirus B3‐infected mice. (A): Bar graphs represent the mean ± SEM of CD115⁺CD11b⁺Ly6C^highCCR2^highCXC3CR1^low and CD115⁺CD11b⁺Ly6C^middleCCR2^highCXC3CR^low positive cells in the blood of control mice (open bar) and CVB3‐infected mice (closed bar) injected with PBS or MSC, expressed as the percentage of Ly6C^high and Ly6C^middle positive cells, respectively with n = 8–9 per group and **, p <  .01; ***, p <  .001. (B): The panel represents dot plots of blood CD115⁺CD11b⁺Ly6C^highCCR2^high CXC3CR1^low and CD115⁺CD11b⁺Ly6C^middleCCR2^highCXC3CR^low positive cells as percentage of Ly6C^high or Ly6C^middle cells, as indicated. (C): Bar graphs represent the mean ± SEM of CD115⁺CD11b⁺LyC6^lowCCR2^low CXC3CR^high positive cells in the blood of control mice (open bar) and CVB3‐infected mice (closed bar) injected with PBS or MSC, expressed as the percentage of Ly6C^low positive cells with n = 8–9 per group and **, p < .01. (D): The panel represents dot plots of blood anti‐inflammatory CD115⁺CD11b⁺Ly6C^lowCCR2^lowCXC3CR^high positive cells as the percentage of Ly6C^low cells, as indicated. Abbreviations: CCR2, chemokine (C‐C motif) receptor‐2; CVB3, coxsackievirus B3; CX3CL1, chemokine (C‐X3‐C motif) ligand‐1; MSC, mesenchymal stromal cell.