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. 2017 May 23;19:59. doi: 10.1186/s13058-017-0845-2

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Ex-vivo and intraoperative workflows. a Ex-vivo workflow from generation of spectra by mass spectrometry (MS) analysis of surgical aerosol through to model building by multivariate statistics leading to ex-vivo recognition of tissue in real time. b Intraoperative workflow from generation of spectra in real time by on-line MS analysis, through to determination of margin status by histopathological assessment and correlation to iKnife results