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. 2017 May 20;130(10):1211–1217. doi: 10.4103/0366-6999.205850

Figure 2.

Figure 2

IL-12 increases the expression of mammalian target of rapamycin and S6 kinase, which was blocked by rapamycin. The peripheral blood mononuclear cells obtained from IPA mice, CTX + IPA mice, CTX + IPA mice treated with IL-12 or rapamycin, and control animals were detected using flow cytometry 7 days after intranasal inoculation of Aspergillus fumigatus. Side scatter and CD8a were used to gate on CD8+ T-lymphocytes, and CD44+ CD45+ CD62+/− cells represent CD8+ effector memory T-cells. The data are presented as the mean ± standard deviation. *P < 0.05. CTX: Cyclophosphamide; IPA: Invasive pulmonary aspergillosis; IL: Interleukin.