Table 4.
Comparison of neutralizing antibody titers against homologous and heterologous subtypes reported in single studies.
| Vaccine | N of doses | Antibody titer against TBEV-FE or TBEV-Sib strains | Antibody titer against TBEV-Eu strains | Difference† | Ref |
|---|---|---|---|---|---|
| FSME-Immun | 2 | Oshima 5–10: 40.0§¶* Sofjin: 47.6§¶* |
Hochosterwitz : 87.2§¶* | Kruskal-Wallis test: H = 4.55, p = 0.10 | [43] |
| IR99–2f7: 58.4§* KH98–5: 37.6§* VL99-m11: 62.2§* |
Hochosterwitz: 96.7§* | Kruskal-Wallis test: H = 5.02, p = 0.17 | [44] | ||
| 3 | Oshima 5–10: 80.0§^* Sofjin: 63.5§^* |
Hochosterwitz: 127.0§^* | Kruskal-Wallis test: H = 2.29, p = 0.32 | [43] | |
| Sofjin: 319** Oshima 5–10: 409** Vasilchenko: 224** |
Neudörfl: 360** K 23: 338** |
ANOVA: F = 2.05, p = 0.089 | [51] | ||
| Encepur | 3 | Sofjin: 56* | K 23: 307*; IX 10: 134*; Hypr: 110*; Trpisovsky: 114*; Petracova: 129*; 274/II: 110*; Gbelce: 98*; Cg 1: 55*; Dobrostan: 31*; Absettarov: 46* | ANOVA: F = 16.94, p < 0.001. Tukey post test: least significant difference in mean loge titers at 5% level is 0.69. Mean loge titer against Sofjin strain is significantly lower than those against 4 of 10 TBEV-Eu strains (K23, IX 10, Trpisovsky and Petracova) | [40] |
Notes:
†Comparison was performed since none of the papers had reported results of statistical tests.
§Calculated values.
¶Two subjects had anti-Japanese encephalitis virus antibodies and were excluded; the authors reported GMTs of 44, 43 and 65 against Oshima 5–10, Sofjin and Hochosterwitz strains, respectively.^ One subject had anti-JEV antibodies and was excluded.
*Geometric mean titers are reported.
**Mean microneutralization titers are reported. TBEV-Eu, European subtype of TBEV; TBEV-FE, Far Eastern subtype of TBEV; TBEV-Sib, Siberian subtype of TBEV.