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. 2014 Dec 17;10(10):3048–3059. doi: 10.4161/21645515.2014.985498

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© 2014 The Author(s). Published with license by Taylor & Francis Group, LLC

This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.

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Figure 3. — Antigen-specific HLA DR3 tg mouse IL-4 responses stimulated by tick SGH and immunoinformatics-predicted tick salivary epitopes in control-, SGH-, and peptide-vaccinated mice. Whole SGH, peptide pool and individual epitopes were assayed for T cell reactivity by IL-4 ELISpot assay using splenocytes isolated from vaccinated mice. Data are the mean spot-forming cells (SFC) over background per million splenocytes that secreted cytokines in response to antigen-specific stimulation. Individual subject average responses from experimental vaccination arms are represented as: control immunizations (▪), SGH immunizations (○), naked peptide pool (NPP) immunizations (▴), liposomal peptide pool (LPP) (▿). The mean cytokine responses across all subjects are represented by white bars. The 50 SFC over background per million splenocytes cutoff is denoted by the dotted line. Statistical significance (P < 0.05) is noted by *.