Table 2A.
Distribution of specific anti-EV71 IgG subtypes in ICR immunized mice with vEV71 and iEV71 antigens
| OD405nm of ELISA for EV71-specific IgG |
|||||
|---|---|---|---|---|---|
| Immunogen | IgG1 OD (S.D.) | IgG2a OD (S.D.) | IgG2b OD (S.D.) | IgG3 OD (S.D.) | IgG1:IgG2a |
| vEV71 | 0.31 (0.05) | 0.08 (0.02) | 0.26 (0.006) | 0.09 (0.01) | 4:1 |
| vEV71+vCVA16 | 0.20 (0.04) | 0.07 (0.01) | 0.22 (0.002) | 0.08 (0.02) | 3:1 |
| iEV71 | 0.18 (0.04) | 0.05 (0.02) | 0.22 (0.01) | 0.07 (0.02) | 3:1 |
| iEV71+iCVA16 | 0.21 (0.02) | 0.06 (0.02) | 0.19 (0.01) | 0.06 (0.02) | 3:1 |
Groups of mice received vEV71, iEV71, vCVA16+vEV71 or iCVA16+iEV71. Mouse sera were collected by tail vein bleeding at the 6th week post-immunization and assayed for specific anti-EV71 IgG subtypes by ELISA. Results are presented as the mean ± SD of three independent experiments.