Table II.
Cross-sectional Analysis of 25(OH)D Status with Lipids at ARIC visit 2 (1990–1992)
| Model 1* | Model 2† | Model 3‡ | |
|---|---|---|---|
| Total cholesterol, mg/dl | |||
| N | 13038 | 12929 | 12842 |
| Continuous [per 10 ng/ml lower 25(OH)D] | −0.68 (−1.53, 0.17) | −1.09 (−1.96, −0.22) | −1.04 (−1.91, −0.16) |
| Optimal (≥30 ng/ml) | Reference | Reference | Reference |
| Deficient (<20 ng/ml) | −0.49 (−2.44, 1.46) | −1.38 (−3.38, 0.63) | −1.37 (−3.38, 0.64) |
| LDL-C, mg/dl | |||
| N | 12814 | 12707 | 12621 |
| Continuous [per 10 ng/ml lower 25(OH)D] | 0.89 (0.09, 1.70) | 0.26 (−0.56, 1.09) | 0.42 (−0.41, 1.25) |
| Optimal (≥30 ng/ml) | Reference | Reference | Reference |
| Deficient (<20 ng/ml) | 2.64 (0.79, 4.49) | 1.22 (−0.67, 3.12) | 1.48 (−0.42, 3.38) |
| HDL-C, mg/dl | |||
| N | 12999 | 12891 | 12804 |
| Continuous [per 10 ng/ml lower 25(OH)D] | −2.51 (−2.85, −2.18) | −1.38 (−1.71, −1.06) | −1.39 (−1.72, −1.07) |
| Optimal (≥30 ng/ml) | Reference | Reference | Reference |
| Deficient (<20 ng/ml) | −5.48 (−6.25, −4.72) | −2.94 (−3.69, −2.19) | −2.94 (−3.69, −2.19) |
| TG, mg/dl | |||
| N | 13036 | 12927 | 12840 |
| Continuous [per 10 ng/ml lower 25(OH)D] | 5.33 (3.46, 7.20) | 0.67 (−1.21, 2.56) | 0.13 (−1.72, 1.99) |
| Optimal (≥30 ng/ml) | Reference | Reference | Reference |
| Deficient (<20 ng/ml) | 12.75 (8.45, 17.04) | 2.51 (−1.81, 6.84) | 1.09 (−3.17, 5.35) |
| Non-HDL-C, mg/dl | |||
| N | 12998 | 12890 | 12803 |
| Continuous [per 10 ng/ml lower 25(OH)D] | 1.87 (0.96, 2.77) | 0.32 (−0.60, 1.25) | 0.39 (−0.54, 1.31) |
| Optimal (≥30 ng/ml) | Reference | Reference | Reference |
| Deficient (<20 ng/ml) | 5.05 (2.96, 7.13) | 1.61 (−0.51, 3.73) | 1.62 (−0.50, 3.73) |
| TC/HDL-C | |||
| N | 12998 | 12890 | 12803 |
| Continuous [per 10 ng/ml lower 25(OH)D] | 0.21 (0.17, 0.25) | 0.10 (0.06, 0.14) | 0.10 (0.06, 0.14) |
| Optimal (≥30 ng/ml) | Reference | Reference | Reference |
| Deficient (<20 ng/ml) | 0.47 (0.38, 0.56) | 0.23 (0.14, 0.32) | 0.23 (0.14, 0.32) |
*
Model 1 adjusted for age, sex and race/center
†
Model 2 additionally adjusted for lifestyle factors (education, BMI, WC, physical activity, smoking, current alcohol)
‡
Model 3 additionally adjusted for other CVD risk factors (hypertension, diabetes, eGFR) and for use of lipid lowering therapy
Abbreviations: LDL-C, low-density lipoprotein cholesterol; HDL-C, high-density lipoprotein cholesterol; TG, triglycerides; BMI, body mass index; WC, waist circumference; CVD, cardiovascular disease; eGFR, estimated glomerular filtration rate