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Western blot analysis demonstrated that the protein expression levels of p-HER2, HER2, PI3K, p-Akt and Akt were markedly reduced when OS xenograft tumors were injected with Lv-shFASN compared with injection with Lv-negative. HER2, human epidermal growth factor receptor 2; PI3K, phosphoinositide 3-kinase; Akt, protein kinase B; p, phosphorylated; Lv, Lentivirus vector; sh, small hairpin; FASN, fatty acid synthase; OS, osteosarcoma; Lv-negative, control group.
