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. 2004 Dec 17;102(2):491–496. doi: 10.1073/pnas.0408305102

Fig. 3.

Fig. 3.

Requirement of DARPP-32 in the activation of ERK in the striatum by drugs of abuse. (a) Immunoblot analysis (quantification in Right) of striatal extracts from wild-type (wt) and DARPP-32-knockout (KO) mice 15 min after i.p. injection of saline or d-amph (10 mg/kg). (b) Immunoblot analysis of prefrontal cortex extracts as in a. (c) Quantification of P-ERK-positive cells in sections of the nucleus accumbens from wt and DARPP-32-KO mice 10 min after injection of d-amph (10 mg/kg, i.p.) or cocaine (20 mg/kg, i.p.), or 20 min after injection of morphine (5 mg/kg, s.c.), nicotine (0.4 mg/kg, s.c.), or THC (1 mg/kg, i.p.), and their respective vehicle-treated controls. Data are means ± SEM (five mice per group, drug-treated vs. control: *, P < 0.05; KO vs. wt: º, P < 0.05).