Table II.
Effect of apigenin on body weight, liver weight, AS index, TC, LDL-C, and SOD (mean ± SD) of the high-fat model mice.
| Groups | Initial body weight | Final body weight | Liver weight | AS index | Initial TC | Final TC | TG | LDL-C | SOD |
|---|---|---|---|---|---|---|---|---|---|
| Control | 22.05±1.40 | 34.05±1.58 | 3.49±0.45 | 0.58±0.29 | 2.13±0.25 | 2.68±0.53 | 1.90±0.34 | 0.57±0.26 | 150.18±9.98 |
| Model | 22.68±2.01 | 36.94±2.07a | 4.08±0.40a | 1.04±0.58b | 2.30±0.46 | 4.53±1.19a | 2.56±0.78a | 1.78±0.78a | 113.56±21.09a |
| Low-dose apigenin | 22.8±1.33 | 36.51±2.25 | 3.9±0.42 | 1.01±0.65 | 2.31±0.44 | 4.07±0.98 | 2.41±0.45 | 1.45±0.89 | 129.65±20.44 |
| Moderate-dose apigenin | 23.78±1.81 | 36.91±1.74 | 3.9±0.4 | 1.05±0.67 | 2.35±0.24 | 4.34±0.81 | 2.56±0.87 | 1.50±0.73c | 125.34±18.65 |
| High-dose apigenin | 22.58±2.00 | 34.97±2.03d | 3.79±0.36 | 0.67±0.33d | 2.39±0.34 | 3.29±0.89c | 2.14±0.54d | 0.80±9.54d | 127.38±20.90c |
| Simvastatin | 23.06±1.61 | 35.88±2.21 | 3.87±0.39 | 0.66±0.22d | 2.30±0.42 | 4.01±1.12c | 2.16±0.54d | 1.08±0.50c | 136.76±19.98d |
a
Based on a comparison with the control group, P<0.01
b
based on a comparison with the control group, P<0.05
c
based on a comparison with the control group, P<0.01
d
based on a comparison with the control group, P<0.05. AS, atherosclerosis; TC, total cholesterol; LDL-C, low-density lipoprotein cholesterol; SOD, superoxide dismutase; TG, triglyceride.