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. 2017 Mar 10;13(5):1993–1999. doi: 10.3892/etm.2017.4218

Figure 5.

Figure 5.

Effects of PCSK9 siRNA on ER stress-associated proteins in A549 cells. (A) A549 cells were transfected with PCSK9 siRNA or control siRNA for 48 h prior to being subjected to protein extraction and western blot analysis with the indicated antibodies. (B) Quantified protein levels relative to GAPDH (loading control) are presented. Values are expressed as the mean ± standard deviation (n=3). The ratio of protein/COXIV (GAPDH) in control siRNA group was assigned as ‘1’ and the ratio of protein/COXIV (GAPDH) in PCSK9 siRNA group was assigned as proportion of control siRNA group compared to PCSK9 siRNA group. *P<0.05 vs. control siRNA. ER, endoplasmic reticulum; siRNA, small interfering RNA; PCSK9, proprotein convertase subtilisin/kexin type 9; GRP78, 78 kDa glucose-regulated protein; p-eIF2, phosphorylated eukaryotic initiation factor 2; PERK, protein kinase R-like ER kinase.