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. 2017 Mar 2;13(5):1702–1710. doi: 10.3892/etm.2017.4171

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Copyright: © Chen et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 4. — Effects of miR-98 mimics and a miR-98 inhibitor on the apoptosis of ox-LDL-treated HUVECs. (A) The protein expression levels of Bcl-2 were upregulated, and those of LOX-1, Bax and cleaved caspase-3 were downregulated, in HUVECs transfected with miR-98 mimics, as determined by western blotting. (B and C) Ox-LDL-induced apoptosis levels were decreased in HUVECs transfected with miR-98 mimics, whereas they were increased in HUVECs transfected with a miR-98 inhibitor, as shown by an Annexin V/PI dual-staining assay. (D) miR-98 mimics alleviated, whereas a miR-98 inhibitor enhanced, cellular apoptosis and pyknosis in ox-LDL-treated HUVECs, as demonstrated by the Hoechst 33342 staining assay. *P<0.05, vs. the vehicle and ox-LDL treatment group. Oligo, oligonucleotide; miR-98, microRNA-98; ox-LDL, oxidized low-density lipoprotein; HUVECs, human umbilical vein endothelial cells; Bcl-2, B-cell lymphoma-2; LOX-1, lectin-like oxidized low-density lipoprotein receptor 1; Bax, Bcl-2-associated X protein; PI, propidium iodide.