Sleep disturbance score at pre-quit and 1-week Post-TQD by treatment arm and abstinence status at 1-week Post-TQD (smoking n = 627 vs. abstinent n = 509). Among those who were abstinent, all groups exhibited an increase in sleep disturbance, but the effect was significantly large in the TN and varenicline groups, compared to the placebo group (treatment arm × visit interaction, p = 0.03). In contrast, among those who either never quit smoking or relapsed, there was no treatment × visit interaction (p = 0.25). The three-way NMR × treatment arm × abstinence status interaction was not significant. Mean +/−standard error